Membrane Structure and ß-Amyloid
The neurotoxic peptide ß-amyloid is involved in the development of Alzheimer‘s disease, but the detailed way of action is still unknown. Our investigations focus on potential membrane interactions of the monomeric peptide or small oligomers of ß-amyloid.
Diffraction pattern obtained on the Membrane Diffractometer V1 and resulting neutron scattering length density profiles of lipid membanes in interaction with partially deuterated ß-amyloid(25-35).
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Dante S, Hauß T, Dencher NA: β-amyloid 25 to 35 is intercalated in anionic and zwitterionic lipid membranes to different extents. Biophysical Journal 2002, 83(5):2610-2616.
Dante S, Hauß T, Brand A, Dencher NA: Membrane fusogenic activity of the Alzheimer’s peptide Aβ(1-42) demonstrated by small-angle neutron scattering. Journal of Molecular Biology 2008, 376(2):393-404.
