Structure of the month - August 2005


Figure 1. Left: The crystal structure of exotoxin A (orange) bound to its target eEF2 (grey), which is inactivated by the ADP-ribosylation transferred to the diphthamide residue (labelled DIPH). The TAD molecule is a nonhydrolyzable NAD analogue. Right: Close-up on the active site of the toxin enzyme in the Michaelis complex. The blue dotted line connects the two atoms to be connected at the end of the reaction.


Table 1. Statistics for data collection and refinement of the two structures.