Structure of the month - August 2005

Andersen_August05_fig1

Figure 1. Left: The crystal structure of exotoxin A (orange) bound to its target eEF2 (grey), which is inactivated by the ADP-ribosylation transferred to the diphthamide residue (labelled DIPH). The TAD molecule is a nonhydrolyzable NAD analogue. Right: Close-up on the active site of the toxin enzyme in the Michaelis complex. The blue dotted line connects the two atoms to be connected at the end of the reaction.


Andersen_August05_tab1_800

Table 1. Statistics for data collection and refinement of the two structures.