Structure of the month - September 2007


Figure 1. Comparison of InlA/hEC1 (human, blue) and InlAm/mEC1 (murine, red) complexes. Critical substitutions between human and murine EC1 domains are shown as ball-and-stick, solvent-exposed substitutions as spheres (differences involving charged residues are marked in red and blue, all others in beige).


Figure 2. The carboxylate of Glu16mEC1, well defined in the 2FO-FC difference electron density (blue, contoured at 1σ), is forced to occupy the hydrophobic Pro16hEC1 binding pocket of InlA.


Table 1. X-ray data collection and refinement statistics.