Structure of the month - January 2013

Table 1.

Figure 1.

DegQ from Legionella fallonii is a chaperone-protease responsible for protein quality control in the bacterial periplasm. A DegQ 12-mer composed of 4 trimers (red, blue, yellow, green) is shown in surface representation. To visualize the proteolytic activity of the 12-mer, fragments of a misfolded substrate molecule (purple) undergoing degradation have been manually added. Macrophages infected with Legionella bacteria are shown in the background.

Figure 2. 

Model of a DegQ molecule in the process of encapsulating a substrate molecule. DegQ trimers (red, blue, yellow, green) are shown in surface representation and a substrate molecule as ribbons (white).