Structure of the month - December 2010


Figure 1.  The overall structure of T. maritima RNase H2 in complex with nucleic acid substrate – a 12-mer double-stranded DNA with single ribonucleotide. The protein is shown in green (the catalytic domain) and cyan (C-terminal helical domain). The nucleic acid is shown in purple with the single ribonucleotide in red. The carboxylate residues forming the active site are shown in orange ball-and-stick and the tyrosine residue at the heart of the RNA-DNA junction recognition module in yellow. Two magnesium ion bound at the active site are shown as purple spheres.

Table 1. Diffraction data and refinement statistics. Values in parantheses are for highest resolution shell.