HZB Newsroom

Sear results - Keyword: Corona

  • <p>The MX team at BESSY II specialises in analysing protein structures. This can also accelerate the development of drugs against COVID-19.</p>
    News
    11.08.2021
    HZB coordinates European collaboration to develop active agents against Corona
    X-ray structure analysis at BESSY II enables the systematic testing of many thousands of molecules that could inhibit the reproduction and virulence of SARS-CoV2 viruses. Now, a team at HZB with partners from Austria and the Czech Republic has set up the NECESSITY project to investigate more than 8000 compounds in a high-throughput procedure and develop active agents against COVID-19.

  • <p>DESY researcher Wiebke Ewert shows on a so-called electron density map where a drug candidate (green) binds to the main protease of the corona virus (blue).</p>
    News
    29.06.2021
    Synchrotrons accelerate corona research
    Information by the German Committee Research with Synchrotron Radiation (KFS).

    Synchrotron light sources were originally built to study particles. Today, they are even used in the fight against COVID-19. The projects are as diverse as the fields of the synchrotron users, who come from universities, research institutions and companies like BioNTech.

  • <p>For the study, the enzyme endothiapepsin (grey) was combined with molecules from the fragment library. The analysis shows that numerous substances are able to dock to the enzyme (blue and orange molecules). Every substance found is a potential starting point for the development of larger molecules.</p>
    Science Highlight
    13.07.2020
    New substance library to accelerate the search for active compounds
    In order to accelerate the systematic development of drugs, the MX team at the Helmholtz-Zentrum Berlin (HZB) and the Drug Design Group at the University of Marburg have established a new substance library. It consists of 1103 organic molecules that could be used as building blocks for new drugs. The MX team has now validated this library in collaboration with the FragMAX group at MAX IV. The substance library of the HZB is available for research worldwide and also plays a role in the search for substances active against SARS-CoV-2.

  • <p>A novel coronavirus (SARS-CoV-2) is spreading worldwide and can cause severe respiratory symptoms (COVID-19).&nbsp;</p>
    News
    04.05.2020
    04.05.2020 - #Corona: HZB resumes operation step by step
    After a careful assessment of the situation, the management decided that operations at HZB would be resumed step by step from 4 May onwards. Strict security regulations apply. BESSY II will be available again for in-house research from 11 May. For Sars-CoV-2-relevant measurements a fast access to BESSY II has been established.
  • <p>Protein crystals are analysed in the MX laboratory at BESSY II with hard X-rays.</p>
    News
    29.04.2020
    Corona research: Consortium of Berlin research and industry seeks active ingredients

    The Berlin biotech company Molox GmbH and a team at the Helmholtz-Zentrum Berlin (HZB) have initiated a consortium of regional research groups and BASF. Together, they want to identify a starting point for the development of a potential active substance against the new coronavirus. Targets of potential inhibitors will be SARS-CoV2 proteins that promote the spread or infectivity of the viruses. Scientists from Freie Universität Berlin are also involved in the research work.

  • <p>Schematic representation of the coronavirus protease. The enzyme comes as a dimer consisting of two identical molecules. A part of the dimer is shown in colour (green and purple), the other in grey. The small molecule in yellow binds to the active centre of the protease and could be used as blueprint for an inhibitor.</p>
    News
    02.04.2020
    Corona research at BESSY II: Two days of measuring operation to find the right key
    The Berlin Synchrotron Source BESSY II of the Helmholtz-Zentrum Berlin (HZB) will resume operation for two days. Scientists intend to use the intense X-ray radiation from BESSY II to search for active substances against the corona virus SARS-CoV2. Almost two hundred samples from an important protein of the virus will be examined in the coming hours. The samples are saturated with different molecules that could be used as components of active substances. The analyses will show whether certain molecules can dock particularly well to the protein molecule and thus hinder the reproduction of the virus. These molecules are best candidates as components of a future drug. 
  • <p>Schematic representation of the coronavirus protease. The enzyme comes as a dimer consisting of two identical molecules. A part of the dimer is shown in colour (green and purple), the other in grey. The small molecule in yellow binds to the active centre of the protease and could be used as blueprint for an inhibitor.</p>
    Science Highlight
    19.03.2020
    Coronavirus SARS-CoV2: BESSY II data accelerate drug development
    A coronavirus is keeping the world in suspense. SARS-CoV-2 is highly infectious and can cause severe pneumonia with respiratory distress (COVID-19). Scientists are doing research in order to prevent the viruses from multiplying. A team from the University of Lübeck and from Helmholtz Centre for Infection Research (HZI) has now found a promising approach. Using the high-intensity X-ray light from the Berlin synchrotron source BESSY II, they have decoded the three-dimensional architecture of the main protease of SARS-CoV-2. This protein is involved in the reproduction of the virus. Analysing its 3D architecture allows the systematic development of drugs which inhibit the reproduction of the virus.