HZB and Freie Universität Berlin are establishing the joint research group “Macromolecular Crystallography”
The teams of Freie Universität Berlin and Helmholtz Zentrum Berlin are engaged in the of training young scientists. The participants produce samples and examine at the MX beamlines of BESSY II.
For eight years, HZB’s “Macromolecular Crystallography” workgroup has been successfully cooperating with the “Structural Biochemistry” research group headed by Prof. Markus Wahl at the Freie Universität Berlin. They are about to intensify this cooperation. The two institutes are establishing a joint research group dedicated to studying the biochemistry of genetic information processing. This research group benefits in particular from access to the three MX beamlines, where it can study protein crystals using the synchrotron light from BESSY II.
“We are thrilled at how this cooperation agreement gives our workgroup a strong scientific connection, which will be fruitful for everyone involved,” Dr. Manfred Weiss, head of the HZB group “Macromolecular Crystallography” said at the inauguration of the research group on 22 February 2017.
While the HZB is primarily working on enhancing the instrumentation and methodological aspects of macromolecular crystallography, the group of the Freie Universität Berlin is introducing its expertise in the field of structure–function relationships in gene regulation. “We will benefit especially from the HZB group’s expertise in crystallographic methods of drug discovery,” Prof. Dr. Markus Wahl is convinced.
The teams of Freie Universität Berlin and Helmholtz Zentrum Berlin have been cooperating highly successfully for a long time already and, among other things, are actively engaged in the of training young scientists. Together with the Max Delbrück Center for Molecular Medicine, they offer a methodological course for students, where the participants can produce samples and examine them at the MX beamlines of BESSY II. This practical education for budding biochemists is unique in Germany. The graduates become sought-after experts in a branch of research and economics that is very important in the Capital Region.
A significant contribution to this development came from the Joint MX-Laboratory, which has combined the expertise of five partners since 2010: researchers of Humboldt Universität zu Berlin, Freie Universität Berlin, the Max Delbrück Center and the Leibniz-Institut für Molekulare Pharmakologie enjoy easy access to the crystallography experimental stations at BESSY II and carry out joint research projects. “The Joint MX-Lab is a great success story for all partners involved and should be continued,” says Manfred Weiss.
- Joint power instead of duplicate structures:Berlin’s research community is further advancing its research excellence by establishing a high-performance, cross-institutional infrastructure for data and AI. With a joint agreement signed on 18 September 2026, the Berlin University Alliance (BUA), the Helmholtz-Zentrum Berlin (HZB) and the Zuse Institute Berlin (ZIB) are paving the way for a joint data science and AI centre in Berlin-Dahlem and Adlershof.
- New technique could make MRI more preciseA team of researchers at the University of Stuttgart and HZB has developed a new method that could make MRI even more precise by eliminating “dead time,” a key limiting factor in the measurement process, thereby enabling the detection of signals that are lost using conventional methods. This method opens up new possibilities for medical diagnostics and non-destructive materials testing. The research team presents the new approach in Science Advances.
- BESSY II: High-resolution insights into individual biomolecules and catalystsVery small biological samples and even individual biomolecules can now be examined under near-physiological conditions with high confidence at the BESSY II infrared beamline with a newly validated and improved technique: The nanoscale infrared spectroscopy (s-SNOM) with ultra-thin silicon-based membranes. An international team demonstrated after an initial proof of concept, that high-resolution (a few tens of nanometres) nano-IR measurements reliably match expected far-field IR spectra in an aqueous environment. This methodological advance provides a solid foundation for studying biomaterials or observing catalytic processes in a liquid environment.