Corona research: Consortium of Berlin research and industry seeks active ingredients
Protein crystals are analysed in the MX laboratory at BESSY II with hard X-rays. © C. Feiler/HZB
At BESSY II, Prof. Rolf Hilgenfeld (Uni Lübeck) was able to analyse an important protein of the SARS-CoV2 virus, the viral main protease which enables the virus to multiply. © H.Tabermann/HZB
The Berlin biotech company Molox GmbH and a team at the Helmholtz-Zentrum Berlin (HZB) have initiated a consortium of regional research groups and BASF. Together, they want to identify a starting point for the development of a potential active substance against the new coronavirus. Targets of potential inhibitors will be SARS-CoV2 proteins that promote the spread or infectivity of the viruses. Scientists from Freie Universität Berlin are also involved in the research work.
"Berlin combines important large-scale infrastructure with an excellent network of academic and industrial structural biologists and biochemists. The distances here are short, but resources and expertise must be strategically coordinated to be successful," says Dr. Holger von Moeller, the owner of the biotech company Molox.
Access to synchrotron radiation is essential for the success of the project. This particularly intense radiation is provided by the Berlin Electron Storage Ring for Synchrotron Radiation (BESSY II), which is operated by the HZB.
Several research groups at Freie Universität Berlin led by Prof. Markus Wahl, Prof. Christian Freund, Dr. Ursula Neu, and Prof. Sutapa Chakrabarti are working with Molox to produce the proteins and then crystallize them.
"The HZB is making all existing infrastructures available to the joint project," explains Dr. Manfred Weiss, head of the Research Group Macromolecular Crystallography (MX) at HZB.
BASF is the first project partner from the chemical industry to provide funds to start the investigations. Protein crystals will be saturated with potential inhibitors and subsequently analysed on the MX beamlines of BESSY II. In this way it can be discovered which compounds are particularly good at inhibiting the function of the protein - these should then be the starting points for the development of active substances.
The consortium is currently negotiating with other partners in order to acquire them and their substance libraries. "We are looking forward to this joint project and hope that we will be able to identify new potential active substances against SARS-CoV-2 very quickly", says Dr. Christian Feiler, project leader at HZB.
- What vibrating molecules might reveal about cell biologyInfrared vibrational spectroscopy at BESSY II can be used to create high-resolution maps of molecules inside live cells and cell organelles in native aqueous environment, according to a new study by a team from HZB and Humboldt University in Berlin. Nano-IR spectroscopy with s-SNOM at the IRIS beamline is now suitable for examining tiny biological samples in liquid medium in the nanometre range and generating infrared images of molecular vibrations with nanometre resolution. It is even possible to obtain 3D information. To test the method, the team grew fibroblasts on a highly transparent SiC membrane and examined them in vivo. This method will provide new insights into cell biology.
- Technology Transfer Prize Ceremony 2025This year’s Technology Transfer Prize Ceremony will take place on October 13 at 2 pm in the Lecture Hall, BESSY II Building, Adlershof.
- Porous Radical Organic framework improves lithium-sulphur batteriesA team led by Prof. Yan Lu, HZB, and Prof. Arne Thomas, Technical University of Berlin, has developed a material that enhances the capacity and stability of lithium-sulphur batteries. The material is based on polymers that form a framework with open pores (known as radical-cationic covalent organic frameworks or COFs). Catalytically accelerated reactions take place in these pores, firmly trapping polysulphides, which would shorten the battery life. Some of the experimental analyses were conducted at the BAMline at BESSY II.