• Longstaff, C.; Varju, I.; Sòtonyi, P.; Szabó, L.; Krumrey, M.; Hoell, A.; Bóta, A.; Varga, Z.; Komorowicz, E.; Kolev, K.: Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones. Journal of Biological Chemistry 288 (2013), p. 6946-6956

10.1074/jbc.M112.404301
Open Access Version

Abstract:
Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essential factors in thrombus stability. Significance: Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.