Invitation to the HZB Science Slam: TODAY at 18.30 o’clock in Adlershof

Many diseases are linked to malfunctions of proteins in the organism. The three-dimensional architecture of these molecules is often highly complex, but it can provide valuable insights into biological processes and the development of drugs. X-ray diffraction at the MX beamlines of BESSY II can be used to decipher the 3D structure of proteins. To date, more than 5000 structures have been solved at the three MX beamlines. Here, we present a review and an outlook with  Manfred Weiss, head of the research group for macromolecular crystallography. 

Teeth are composites of mineral and protein, with a bulk of bony dentin that is highly porous. This structure is allows teeth to be both strong and sensitive. Besides calcium and phosphate, teeth contain trace elements such as zinc. Using complementary microscopy imaging techniques, a team from Charité Berlin, TU Berlin and HZB has quantified the distribution of natural zinc along and across teeth in 3 dimensions. The team found that, as porosity in dentine increases towards the pulp, zinc concentration increases 5~10 fold. These results help to understand the influence of widely-used zinc-containing biomaterials (e.g. filling) and could inspire improvements in dental medicine.

The Bavarian State Office for the Preservation of Historical Monuments (BLfD) has sent a rare artefact from the Middle Bronze Age to Berlin for examination using cutting-edge, non-destructive methods. It is a 3,400-year-old bronze sword, unearthed during archaeological excavations in Nördlingen, Swabia, in 2023. Experts have been able to determine how the hilt and blade are connected, as well as how the rare and well-preserved decorations on the pommel were made. This has provided valuable insight into the craft techniques employed in southern Germany during the Bronze Age. The BLfD used 3D computed tomography and X-ray diffraction to analyse internal stresses at the Helmholtz-Zentrum Berlin (HZB), as well as X-ray fluorescence spectroscopy at a BESSY II beamline supervised by the Bundesanstalt für Materialforschung und -prüfung (BAM).