Civantos, A.; Beltrán, A. M.; Dominguez-Trujillo, C.; Garvi, M.D.; Lebrato, J.; Rodriguez-Ortiz, J.A.; Garcia-Moreno, F.; Cauich.Rodriguez, J.V.; Guzman, J.J.; Torres, Y.: Balancing Porosity and Mechanical Properties of Titanium Samples to Favor Cellular Growth against Bacteria. Metals 9 (2019), p. 1039/1-16
10.3390/met9101039
Open Accesn Version

Abstract:
Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the sti ness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this di erence in sti ness but compromise biomechanical behavior. In this work, the relationship between the microstructure (content, size, and shape of pores) and the antibacterial and cellular behavior of samples fabricated by the space-holder technique (50 vol % NH4HCO3 and three ranges of particle sizes) is established. Results are discussed in terms of the best biomechanical properties and biofunctional activity balance (cell biocompatibility and antibacterial behavior). All substrates achieved suitable cell biocompatibility of premioblast and osteoblast in adhesion and proliferation processes. It is worth to highlighting that samples fabricated with the 100–200 m space-holder present better mechanical behavior—in terms of sti ness, microhardness, and yield strength—which make them a very suitable material to replace cortical bone tissues. Those results exposed the relationship between the surface properties and the race of bacteria and mammalian cells for the surface with the aim to promote cellular growth over bacteria.