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Electron density map of the most antiviral active ingredient calpeptin (yellow) binding at the main protease.
SCIENCE HIGHLIGHT
X-ray lightsource at DESY identifies promising candidates for COVID drugs The MX team from HZB examined part of the measurement data with special analysis algorithms in order to identify suitable active substances.
An impression of the placoderm fish living 380 million years ago.
SCIENCE HIGHLIGHT
Tomography brings insights into the early evolution of bones A team of palaeontologists has analysed bones in early fish species an discovered bone cells with imaging methods by HZB scientists.
Artificial and natural interzones on a tooth restored with non-degradable biomaterials are exposed to mechanical (left: stresses acting in compression, tension and shear) and biological challenges (right: bacterial attachment, penetration, and other interactions with biological media).
NEWS
Dental materials science: HZB is part of a research project funded by DFG Partners also include the Helmholtz-Zentrum Berlin (HZB), a research center for energy materials research, and the Max Planck Institute of Colloids and Interfaces (MPI-KG), which is located in Potsdam.
(a,b) Cryo-electron microscopy of the 2D-grating and the diffraction pattern of a section. (c-e) Magnification shows the 2D Pascal triangular pattern, with the inserted protein molecules.
SCIENCE HIGHLIGHT
Nanopatterns of proteins detected by cryo-electron microscopy A Team at HZB used cryo electron microscopy to detect regular, two-dimensional structures in the form of Pascal triangles, which a Chinese research group assembled from proteins in the laboratory for the first time.
For the study, the enzyme endothiapepsin (grey) was combined with molecules from the fragment library. The analysis shows that numerous substances are able to dock to the enzyme (blue and orange molecules). Every substance found is a potential starting point for the development of larger molecules.
SCIENCE HIGHLIGHT
New substance library to accelerate the search for active compounds In order to accelerate the systematic development of drugs, the MX team at the Helmholtz-Zentrum Berlin (HZB) and the Drug Design Group at the University of Marburg have established a new substance library.
Inside the 3D-structure of a phytochrome a bilin pigment absorbs the photon and rotates, which triggers a signal.
SCIENCE HIGHLIGHT
User research at BESSY II: Insights into the visual perception of plants Plants use light not only for photosynthesis. Although the plant cell does not have eyes, it can still perceive light and thus its environment. Phytochromes, certain turquoise proteins, play the central role in this process.
Protein crystals are analysed in the MX laboratory at BESSY II with hard X-rays.
NEWS
Corona research: Consortium of Berlin research and industry seeks active... The Berlin biotech company Molox GmbH and a team at HZB have initiated a consortium of regional research groups and BASF. They want to identify a starting point for the development of a potential active substance against the new coronavirus.
Schematic representation of the coronavirus protease. The enzyme comes as a dimer consisting of two identical molecules. A part of the dimer is shown in colour (green and purple), the other in grey. The small molecule in yellow binds to the active centre of the protease and could be used as blueprint for an inhibitor.
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Corona research at BESSY II: Two days of measuring operation to find the right... New measurement campaign helps to accelerate the search for active ingredients
Schematic representation of the coronavirus protease. The enzyme comes as a dimer consisting of two identical molecules. A part of the dimer is shown in colour (green and purple), the other in grey. The small molecule in yellow binds to the active centre of the protease and could be used as blueprint for an inhibitor.
SCIENCE HIGHLIGHT
Coronavirus SARS-CoV2: BESSY II data accelerate drug development At the Berlin X-ray source BESSY II, researchers have decoded a protein involved in the replication of the corona virus. Analysing the 3D architecture allows the systematic development of drugs which inhibit the reproduction of the virus.
An individual eye shield is made for each patient to protect the surrounding tissue from the proton beam.
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20 percent more patients were treated with proton therapy in 2019 For more than 20 years, Charité - Universitätsmedizin Berlin and the Helmholtz-Zentrum Berlin (HZB) have jointly offered the irradiation of eye tumors with protons. In 2019, more patients were treated in Berlin-Wannsee than ever before. 276 patients - 20 ...
60s on the new detector were sufficient to obtain the electron density of the PETase enzyme.
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New detector accelerates protein crystallography Compared to the old detector the new one is better, faster and more sensitive. It allows to acquire complete data sets of complex proteins within a very short time.
3D architecture of the cell with different organelles: mitochondria (green), lysosomes (purple), multivesicular bodies (red), endoplasmic reticulum (cream).
SCIENCE HIGHLIGHT
X-ray microscopy at BESSY II: Nanoparticles can change cells Nanoparticles easily enter into cells. How they are distributed and what they do there is now shown for the first time by high-resolution 3D microscopy images from BESSY II: Nanoparticles accumulate in certain organelles of the cell.
Rhodopsin before (left) and after activation by light (right): The activation causes changes in functional groups inside the molecule (magnifying glass), which affect the entire molecule.
SCIENCE HIGHLIGHT
Watching complex molecules at work Novel spectrometer at the IRIS beamline of the BESSY II synchrotron source at the Helmholtz-Zentrum Berlin (HZB) allows analysis of very fast and irreversible reactions and processes.
The study is displayed on the cover of the journal Chemmedchem.
SCIENCE HIGHLIGHT
Cancer research at BESSY II: Binding Mechanisms of Therapeutic Substances... A team has used BESSY II to analyse the possible binding mechanisms in certain therapeutic substances from the tetrazole hydrazide group.
The image shows details such as the vacuole of the parasites (colored in blue and green) inside an infected blood cell.
SCIENCE HIGHLIGHT
X-ray microscopy at BESSY II reveals how antimalaria-drugs might work An international team has now been able to investigate malaria pathogens in red blood cells under natural conditions using X-ray microscopy at BESSY II, ALBA and ESRF. They show which mechanisms are used by active substances to attack the pathogens.
Time-resolved 3D neutron tomography shows the rise of deuterated water in the root system of a lupine plant.
SCIENCE HIGHLIGHT
Faster than ever - neutron tomography detects water uptake by roots The high-speed neutron tomography developed at Helmholtz-Zentrum Berlin (HZB) generates a complete 3D image every 1.5 seconds and is thus seven times faster than before.
Up to three indivudal drops may be placed onto the sample holder.
SCIENCE HIGHLIGHT
New sample holder for protein crystallography A short video by the team shows how proteins in solution can be crystallised directly onto the new sample holders themselves, then analysed using the MX beamlines at BESSY II.
At the MX-Beamlines at BESSY II, Gottfried Palm, Gert Weber and Manfred Weiss could solve the 3D structure of MHETase.
NEWS
FOCUS TOPIC: Using BESSY II to combat plastic waste MHETase was discovered in bacteria and together with a second enzyme - PETase - is able to break down the widely used plastic PET into its basic building blocks.
SCIENCE HIGHLIGHT
Oldest completely preserved lily discovered Already 115 million years ago, tropical flowering plants were apparently very diverse and showed all typical characteristics. This is the conclusion of an international team of researchers led by Clément Coiffard, Museum für Naturkunde Berlin. The team ...
The enzyme MHETase is a huge and complex molecule. MHET-molecules from PET plastic dock at the active site inside the MHETase and are broken down into their basic building blocks.
SCIENCE HIGHLIGHT
"Molecular scissors" for plastic waste MHETase was discovered in bacteria and together with a second enzyme - PETase - is able to break down the widely used plastic PET into its basic building blocks.
Lena Graß has received an award by GBM for her master thesis.
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Outstanding master thesis on the structure and function of a bacterial enzyme... Outstanding master thesis on the structure and function of a bacterial enzyme honoured. Society for Biochemistry and Molecular Biology awards Student.
Computer scientist Andreas Maier, materials researcher Silke Christiansen and medical expert Georg Schett have been awarded with an ERC Synergy Grant.
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ERC Synergy grant with HZB participation Novel X-ray microscope to produce microstructural images in situ and in vivo
Fossils like this 250 million year old skull of a lystrosaurus can be examined very carefully by neutron tomography.
SCIENCE HIGHLIGHT
Neutron tomography: Insights into the interior of teeth, root balls, batteries,... A team of researchers at Helmholtz-Zentrum Berlin (HZB) and European Spallation Source (ESS) has now published a comprehensive overview of neutron-based imaging processes in the renowned journal Materials Today (impact factor 21.6). The authors report on the ...
The magnetosomes form a chain inside the bacteria's cell shows the electron cryotomography (ECT).
SCIENCE HIGHLIGHT
BESSY II sheds light on how the internal compass is constructed in...
Sketch of the Photosystem II.
SCIENCE HIGHLIGHT
Novel soft X-ray spectrometer enables individual steps of photosynthetic water... HZB scientists have developed a novel spectrometer at BESSY II that enables researchers to obtain detailed insights about catalytic processes in metalloenzymes. Their international collaboration was successful in delineating individual steps in the catalytic ...
Sequential tomography of a lupin root (yellowish green) after deuterated water (D2O) was introduced from below. The rising water front (H2O, dark blue) is displaced by the D2O from below over the course of time. The complete sequence can be viewed as a video. Created by Christian Tötzke © University of Potsdam
SCIENCE HIGHLIGHT
User research at BER II: Lupin roots observed in the act of catching water from... Lupins not only produce colourful blossoms but also nutritious beans rich in proteins. Just how these plants draw water approaching their roots in soil has now for the first time been observed in three dimensions by a University of Potsdam team at the HZB-BER ...
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HZB and Freie Universität Berlin establish the joint research group “X-Ray... In May this year, the joint research group "X-Ray Microscopy” was launched, combining the expertise of teams led by Prof. Dr. Gerd Schneider (Helmholtz-Zentrum Berlin) and Prof. Dr. Helge Ewers (Freie Universität Berlin). While Ewers’ group ...
Comparison of the same specimen at the old Beamline (left) and the new HZB-XM-Beamline (right).
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X-Ray microscopy: HZB-TXM is back in operation The X-ray microscope (HZB-TXM) is back in operation. The TXM offers significantly better quality images compared to the former X-ray microscopy station.
The teams of Freie Universität Berlin and Helmholtz Zentrum Berlin are engaged in the of training young scientists. The participants produce samples and examine at the MX beamlines of BESSY II.
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HZB and Freie Universität Berlin are establishing the joint research group... For eight years, HZB’s "Macromolecular Crystallography” workgroup has been successfully cooperating with the "Structural Biochemistry” research group headed by Prof. Markus Wahl at the Freie Universität Berlin. They are about to intensify ...
The newly developed expert system was used to analyse 364 data sets of a specidfic protein crystal, soaked in different fragments.
SCIENCE HIGHLIGHT
Advancing methodology at BESSY II: Automated evaluation speeds up the search... The macromolecular crystallography (MX) beamlines at the BESSY II X-ray source are specially designed to highly automated structural analyses of protein crystals. With up to now more than 2000 solved structures of protein molecules, these beamlines are by far ...
A new generation of sensors: The scales of the petrified cone move upward against gravity, and on drying back to their starting positions.
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User research at BESSY II: How water moves glass In the realm of plants, capillary forces are a widely observed impetus for actuation. They are the physical basis for the expansion of porous materials during uptake of fluid. Such materials include the cones of conifers with their readily observable movement ...
Dentin's biological structure: tubules and mineral nanoparticles embedded in a network of collagen fibers. Image: Jean-Baptiste Forien, © Charité – Universitätsmedizin Berlin
SCIENCE HIGHLIGHT
User research at BESSY II: nanostructures in human teeth Dentin is one of the most durable biological materials in the human body. Researchers from Charité–Universitätsmedizin Berlin were able to show that the reason for this can be traced to its nanostructures and specifically to the interactions between the ...
MXcuBE Meeting from 1st - 2nd of December 2015 at Alba, Barcelona. The meetings make sure that the devenlopment of MXcuBE3 closly fits to the needs of the users. Photo: Jordi Juanhuix/ALBA
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Common platform for macromolecular crystallography at European synchrotrons Researchers use high-intensity X-ray light from synchrotron radiation sources to decipher the structures of biological molecules and thus the blueprints of life. A cooperation agreement has been effective since 2012 to establish common software standards at ...
Proteinkristalle an BESSY II studieren: Dank eines einmaligen Projektes können Studierende der FU Berlin regelmäßig am Snychrotron experimentieren. Das ist nur einer der sichtbaren Erfolge der Kooperation in der Berliner Strukturbiologie. Foto: Silvia Zerbe/HZB
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Gemeinsames Treffen der Strukturbiologen in Berlin: der 6. Joint-MX-Day am 23.... Die Hauptstadt hat sich in den letzten Jahren zu einem Hotspot der Strukturbiologie in Deutschland entwickelt. Entscheidend dazu beigetragen hat das hohe Maß an Kooperation zwischen außeruniversitären Forschungseinrichtungen und Universitäten. Aber auch ...
Prof. Dr. Gerd Schneider becomes a full professur for x-ray microscopy at the Humboldt University Berlin and is the head of the HZB group "Microscopy".
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Gerd Schneider receives a professorship for "X-ray microscopy" at... On 29 April 2015, Gerd Schneider (HZB) accepted the call to a W2-S "X-ray microscopy” professorship at the Department of Physics of Humboldt-Universität zu Berlin. The professorship is associated with heading the workgroup "X-ray microscopy” at ...
Illustration of the complex biostructure of dentin: the dental tubuli (yellow hollow cylinders, diameters appr. 1 micrometer) are surrounded by layers of mineralized collagen fibers (brown rods). The tiny mineral nanoparticles are embedded in the mesh of collagen fibers and not visible here.
SCIENCE HIGHLIGHT
Strong teeth: Nanostructures under stress make teeth crack resistant Human teeth have to serve for a lifetime, despite being subjected to huge forces. But the high failure resistance of dentin in teeth is not fully understood. An interdisciplinary team led by scientists of Charité – Universitätsmedizin Berlin has now ...
The neutron images (left row) detect the distribution of liquids in this filled tooth, whereas the X-ray-CT shows the microstructure and pores in the material. A comparision of both images allows to see which pores are filled with liquids.
SCIENCE HIGHLIGHT
Neutrons and X-rays show how to prepare durable tooth cement There are many ways to mix cements for tooth fillings, but it can be difficult to tell which way works best. Now, a team of scientists from Copenhagen, Denmark, has come up with an answer: They used neutron imaging and x-ray-microtomography at HZB to analyze ...
Patient im Behandlungsstuhl
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2500 Augentumor-Patienten von der Charité mit Protonen am Helmholtz-Zentrum... Am Freitag, dem 21. November 2014, wurde um 16:10 Uhr die Bestrahlungsserie der 2500. Protonentherapiepatientin, am Helmholtz-Zentrum Berlin erfolgreich abgeschlossen. Seit 1998 behandelt die Augenklinik der Charité - Universitätsmedizin Berlin, Campus ...
SCIENCE HIGHLIGHT
“Multi-spectra glasses” for scanning electron microscopy Reflection zone plates produced by HZB enable lighter elements in material samples to be precisely detected using scanning electron microscopy (SEM) by providing high resolution in the range of 50-1120 eV.
SCIENCE HIGHLIGHT
Proteins: New class of materials discovered German-Chinese research team gleans seminal insights into protein crystalline frameworks at HZB's BESSY II
Sebastian Seiffert forscht am HZB-Institut "Weiche Materie und funktionale Materialien" und leitet auch an der Freien Universität Berlin eine Arbeitsgruppe.
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GDCh zeichnet Sebastian Seiffert aus Prof. Dr. Sebastian Seiffert erhält eine weitere Auszeichnung für seine Forschungsarbeit. Die Gesellschaft Deutscher Chemiker (GDCh) hat mitgeteilt, dass Seiffert den Preis für Nachwuchswissenschaftler auf dem Gebiet der Makromolekularen Chemie erhalten wird. ...
SEM image of the membrane.
SCIENCE HIGHLIGHT
“Muscled skin”: Simple formulas describe complex behaviors HZB researchers help chemists understand polymeric "biomimetic" materials' mechanical properties
These scanning electron micrographs show how accurately the three Fresnel zone plates were positioned above one another. 3D X-ray optics of this kind allow the resolutions and optical intensities to be considerably improved.
SCIENCE HIGHLIGHT
Sharper imaging using X-rays HZB team develops three-dimensional volume diffraction optics for X-rays
Crystal structure of human MTH1 in complex with a key inhibitor.Source: Stockholm University, Prof. Pal Stenmark.
SCIENCE HIGHLIGHT
A new concept for the treatment of cancer A team of researchers from five Swedish universities has identified a new way to treat cancer. They present their concept in the journal "Nature". It is based on inhibiting a specific enzyme called MTH1. Cancer cells, unlike normal cells, need MTH1 to ...
Kristalle in ihrer ganzen Schönheit, Form und Farbenvielfalt faszinieren die Gelehrten seit der Antike. Das Internationale Jahr der Kristallographie macht auf die erzielten Fortschritte in allen Lebensbereichen aufmerksam.
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Kristalle in Wissenschaft und Technik: Ergebnisse auf der 22. Jahrestagung der... Die Kristallographie hat enorm zum Fortschritt des 20. und 21. Jahrhundert beigetragen und ein grundlegendes Verständnis von Prozessen in vielen Lebensbereichen ermöglicht. Die Vielfalt der interdisziplinären Wissenschaft zu Struktur und Eigenschaften von ...
Steve Cramer is looking forward to collaborate with the Berlin Team at HZB and FU.
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Humboldt Research Award brings Stephen P. Cramer to Berlin The renowned synchrotron spectroscopy expert Professor Stephen P. Cramer has received a Humboldt Research Award and may now spend up to one year cooperating closely with a team at Helmholtz-Zentrum Berlin (HZB) and Freie Universität Berlin. Cramer was ...
A key feature of the active site of the trypanosomal thiolase is the HDCF-loop (HIS-ASP-CYS-PHE), visualised in light blue.
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Blocking the active site of thiolase Scientists at the University of Oulu, Finland, and at the HZB break new ground for drug discovery research in the fight against sleeping sickness
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Festsymposium zur 1000. Proteinstruktur an BESSY II Im Juli 2013 wurde die 1000. Proteinstruktur veröffentlicht, die auf bei BESSY II gemessenen Daten beruht. Aus diesem Anlass lädt das HZB am Mittwoch, den 16.10.2013, zu einem Festsymposium ein.
Structure of the sugar molecule bound by the enzyme transketolase immediately prior to its being split
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Göttingen scientists use BESSY II to decode basic mechanism underlying... Enzymes are life’s molecular catalysts and figure prominently in cellular metabolism. It has been speculated that in the course of a biochemical reaction enzymes physically bend their substrates to split them. Now for the first time ever, scientists at ...
This sketch demonstrates the principle of measurement which enables to address atom-specific and state-dependent emission of photons. With the help of first principles theory the spectral features can be associated with molecular orbitals.
SCIENCE HIGHLIGHT
Better insight into molecular interactions How exactly atoms and molecules in biochemical solutions or at solid-liquid interfaces do interact, is a question of great importance. Answers will provide insights at processes in catalysts, smart functional materials and even physiological processes in the ...
Dr. Anup Kumar Bera from the department of Quantum Phenomena in Novel Materials convinced the committee with his poster about ‘Haldane chains’.
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International Conference in Neutron Scattering: HZB-contributions awarded More than 800 participants had gathered for the International Conference in Neutron Scattering, held during 8-12 July 2013 in Edinburgh, to discuss advances in neutron research and the advancement of the neutron scattering instruments and techniques. A ...
The inhibitor Ex-527 attaches to the enzyme Sirt-3 (shown here in light grey) and to acetylated ADP ribose; this substance is a product which results from Sirt-3 mediated deacetylation. This blocks the sirtuin’s active center to prevent further deacetylation. This way, the sirtuin has effectively set a permanent trap for itself the first time around.
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1000th protein structure decoded at BESSY II In July of this year, the 1000th protein structure based on measurements obtained at BESSY II was published. The molecule in question belongs to a class of proteins called sirtuins, which are involved in aging, stress, and metabolic processes within the human ...
Dr. Tristan Petit joins the Aziz-Team. Foto: T.Petit
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Humboldt Fellow new addition to Aziz team Starting June 1st, Dr. Tristan Petit will be joining Prof. Dr. Emad Flear Aziz’ team for a two-year postdoc. His Humboldt Foundation Fellowship for Postdoctoral Researchers gave Petit the option to choose his German scientific host. Ultimately, he ...
Structure of Brr2-protein belongs to a family of enzymes that are called “RNA helicases”.
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Discovery of how a key enzyme of the spliceosome exerts its controlling function To sustain life, processes in biological cells have to be strictly controlled both in time and in space. By using the MX-Beamline of synchrotron radiation source BESSY II research workers at the Max Planck Institute for Biophysical Chemistry in Göttingen and ...
With the help of computer simulation, researchers have beenable to calculate the movements and forces between water molecules (small, red-and-white dipoles), a ligand (shown in green),and the protein molecule's water-repellant hollow pocket.
SCIENCE HIGHLIGHT
Water fluctuations mediate lock-and-key fit Without water, life as we know, it would not exist. Nearly every biological binding process that takes place within a cell requires the presence of an aqueous environment. Here, tiny molecules called ligands fit like "keys" into their matching "locks" - ...
Der Pilatus-Detektor (rechts) ist mit dem ASAXS-Instrumentdes HZB am FCM-Strahlrohr der PTB installiert.
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Mit neuem Detektor kleinsten Biomarkern auf der Spur PTB installiert vakuumkompatiblen ortsempfindlichen Röntgendetektor am Elektronenspeicherring BESSY II. Forscher können damit die Größe kontrastarmer Nanoobjekte bestimmen.
On the photo are shown from left to right Manfred Weiss (HZB-MX), Bartosz Sekula (Lodz), Uwe Mueller (HZB-MX) and Anna Bujacz, Bartosz' Ph.D. supervisor.
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MX-Posterprize to Bartosz Sekula, Lodz The prize for the best poster in the field of macromolecular crystallography was awarded toBartosz Sekula from the University of Lodz (Poland). The poster committee unanimously selected the poster titled "Complexes of equine serum albumin with ligands" as ...
With the help of HZB’s x-ray microscope, MAXYMUS, MPICscientists in Mainz, Germany, recently decoded the methodsused by mushrooms and plants to influence Amazon rainforestcloud formation. Organic substances condense on mushroom andplant derived potassium salts resulting in production ofaerosol particles. On these, fog droplets form.
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Rainforest mushrooms as weather makers Whereas in urban areas, soot or dust particles often double as condensation nuclei, in rain-forests, it is mainly organic evaporations from plants, which periodically trigger fog or cloud formation. Now, at HZB’s BESSY II, Max Planck Institute for ...
Von links nach rechts: Martin Jermann, Prof. Dr.-Ing. AnkeKaysser-Pyzalla, Cornelia Yzer, Prof. Dr. Ulrich Frei, Prof. Dr. med.Antonia M. Joussen, Dr. Jutta Koch-Unterseher.Foto: Jennifer Bierbaum/HZB
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Festkolloquium anlässlich des 2000. Patienten bei der Augentumortherapie Die Protonentherapie von Augentumoren wird in Deutschland nur vom Helmholtz-Zentrum Berlin gemeinsam mit der Charité Berlin angeboten, vor kurzem wurde der 2.000. Patient behandelt. Bei ihrem Grußwort auf dem Festkolloquium am 11. Oktober 2012 würdigte ...
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Neues Helmholtz Virtuelles Institut feierlich eröffnet Mit einem Festakt an der Freien Universität Berlin wurde am Montag, dem 19. Dezember, ein neues Helmholtz Virtuelles Institut (HVI) eröffnet, an dem neben dem federführenden Helmholtz-Zentrum Geesthacht in Teltow (HZG) und der Freien Universität Berlin auch ...
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Shedding Light on Luminescence - Scientists at HZB reveal the structure of a... Fluorescent proteins are important investigative tools in the biosciences: Coupled to other proteins, they help us to study the processes of life inside cells and organisms at the molecular level. Fluorescent proteins are made to light up at specific target ...
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2. Joint Berlin MX Day Die in Berlin auf dem Gebiet der Strukturbiologie forschenden Wissenschaftler betreiben seit einem Jahr gemeinsam das Joint Berlin MX Laboratory. Am 17. August findet der zweite gemeinsame Workshop statt. Gastgeber ist diesmal das Max-Delbrück-Centrum in ...
Prof. Dr. Emad Flear Aziz
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Flüssigkeiten im Synchrotron: Mit weicher Röntgenstrahlung der Funktion von... Der Karl-Scheel-Preis 2011 der Physikalischen Gesellschaft zu Berlin geht an Prof. Dr. Emad Flear Azizvon der Freien Universität Berlin und dem Helmholtz-Zentrum Berlin für Materialien und Energie
Vordere Reihe, von links nach rechts: Leona Berndt, ChristianeKowsky, Daniela DalmHintere Reihe, von links nach rechts: Gesa Volkers, XeniaBogdanovic, Britta Girbardt, Christiane Großmann, Dr. ChristianeFenske, Dr. Gottfried Palm, Winfried HinrichsFoto: Uni Greifswald
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Kampf gegen Antibiotika-Resistenzen - Wissenschaftler enttarnen Resistenzprotein Wissenschaftler des Helmholtz-Zentrum Berlin haben mit der Synchrotronstrahlungsquelle BESSY II an der Strukturaufklärung eines Proteins mitgewirkt, das für Antibiotikaresistenzen verantwortlich ist: Mit ihrer Unterstützung ist es Forschern der Universität ...
Das ist die 500ste Proteinstruktur, die am BESSY II ent- schlüsselt wurde. Das Molekül, das im aktiven Zentrum des Proteins zu sehen ist, ist die Vorstufe eines Hemmstoffs für Pim-1. Die Struktur klärten Wissenschaftler von Bayer Healthcare Pharmaceuticals in Berlin auf.
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Von 1 auf 500… - 500ste Protein-Struktur an BESSY II entschlüsselt Haare, Haut, Blutkreislauf und Nervensystem – alles wird von winzigen biologischen Bausteinen gesteuert. Wer nach diesen kleinsten Bausteinen des Lebens forscht, landet automatisch bei ihnen: den Proteinen. Um diese Grundbausteine des Lebens und die ...
The imaged Brandenburg Gate is only a few micrometres in size.The scientists took the green and red pictures of the modelmerely 50 femtoseconds apart.
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Fastest movie in the world recorded Scientists develop a method to film nanostructures
Slice through the nucleus of a mouse adenocarcinoma cellshowing the nucleolus (NU) and the membrane channels runningacross the nucleus (NMC); taken by X-ray nanotomography.Photo: HZB/Schneider
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New microscope reveals ultrastructure of cells HZB researchers can take images of small cellular components in their natural environment – while the cell remains intact
Close-up of the liquid-jet.
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LiXEdrom: Innovative measuring chamber for X-ray study of liquid jets Until now, the only way to study liquids by soft X-ray emission spectroscopy (XES) has been through a membrane window. Now, researchers of Helmholtz-Zentrum Berlin have carried out an XES study of a free micro-liquid jet on the synchrotron.
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Katalase und Methämoglobin: so ähnlich und doch verschieden Wichtige physiologische Prozesse beim Fettabbau und Sauerstofftransport aufgeklärt
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Kristallisationspunkt für Nachwuchswissenschaftler Workshop zur synchrotron-basierten biologischen Strukturforschung am HZB in Adlershof
Die drei Neutronenradiogramme zeigen aufsteigendes Wasser in einer Tomatenpflanze. Die Radiogramme entstehen auf ähnliche Weise wie Röntgenaufnahmen, wobei Neutronen im Gegensatz zu Röntgenstrahlen auch Wasserstoff deutlich zeigen. Der Wasserbehälter, in dem sich die Wurzel der Pflanze befindet, ist aus technischen Gründen nach oben hin abgedichtet worden.
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Wie schnell trinkt die Tomate? Wissenschaftlern am Berliner Hahn-Meitner-Institut ist es erstmals gelungen, in deutlichen Bildern zu beobachten, wie schnell eine Pflanze Wasser aufnimmt. In einer Reihe von Aufnahmen, die einen Tomatensetzling zeigen, kann man genau verfolgen, wie das ...
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Muster im Lebendigen lesen: Erwin Schrödinger Preis 2003 für Dr. Martin Falcke Einer deutsch-amerikanischen Wissenschaftlergruppe ist es gelungen, durch Analyse von Mustern, die von der Kalziumkonzentration in lebenden Zellen gebildet werden, die Funktionsweise von Zellorganellen zu verstehen. Für diese grundlegenden Erkenntnisse ...
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Verkehrsstau in der Nervenzelle vorausgesagt Die Nervenzellen unseres Körpers sind von einem dichten Netz von Wegen durchzogen, auf denen winzige biologische Transporter kleine mit lebenswichtigen Molekülen gefüllte Pakete transportieren. In der Abteilung Theorie des Berliner Hahn-Meitner-Instituts ...
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Neutronen verraten Wasserstoff in Eiweißen Mit immer aufwendigeren Methoden wollen Forscher die feinsten Strukturen auch der lebenden Materie erkunden. So nutzen sie Synchrotronstrahlung und Neutronen, um die atomare Architektur von Proteinen zu enträtseln. Proteine (Eiweiße) sind organische ...